Sample

TCGA-CA-6717-01

Total Number of Mutations Across All Mutation Types

12977

Total number of SBS96 Mutations
12965

Total number of mutations is acceptable

Cosine Similarity

0.986238773

The similarity is great!

Summary: Since both the total number of mutations and cosine similarity of the signature analysis are acceptable, the analysis can be considered useful. Take note of the discrepancies between the reconstructed and observed profiles, if any difference between the models lie within one mutation, then the sample should be flagged

Contributing Signatures:

SBS10b - 30.78%
SBS10a - 24.18%
SBS28 - 9.14%
SBS46 - 6.81%
SBS15 - 5.99%
SBS37 - 5.36%
Total number of DBS78 Mutations
12

Total number of mutations are too low to be considered a good sample

Cosine Similarity

0.810619528

Too low, revise the signature selection

Summary: The total number of mutations is too low, this analysis should be revised and further bootstraps should be performed. Do not use this analysis.

Contributing Signatures:

DBS3 - 47.31%
DBS10 - 34.55%
DBS2 - 8.53%
DBS1 - 8.09%
Total number of ID83 Mutations
0

No mutations found, do not consider as a good sample

Cosine Similarity

0

No matches, revise the signature selection

Summary: The total number of mutations is too low, this analysis should be revised and further bootstraps should be performed. Do not use this analysis.

T-SNE Plot - Sample Similarity

No T-SNE plot can be displayed as no dimensionality_reduction .csv file was inputted. Please refer to Full Report Generation Documentation

Technical Details of Signature Analysis Methods

Signature Databases

  • SBS96: COSMIC_v3.4_SBS_GRCh38

  • DBS78: COSMIC_v3.4_DBS_GRCh38

  • ID83: COSMIC_v3.4_ID_GRCh37

Fitting Method

Sigminer QP