Sample
TCGA-CA-6717-01
Total Number of Mutations Across All Mutation Types
12977
Total number of mutations is acceptable
Cosine Similarity
The similarity is great!
Summary: Since both the total number of mutations and cosine similarity of the signature analysis are acceptable, the analysis can be considered useful. Take note of the discrepancies between the reconstructed and observed profiles, if any difference between the models lie within one mutation, then the sample should be flagged
Contributing Signatures:
| SBS10b | - | 30.78% |
| SBS10a | - | 24.18% |
| SBS28 | - | 9.14% |
| SBS46 | - | 6.81% |
| SBS15 | - | 5.99% |
| SBS37 | - | 5.36% |
Total number of mutations are too low to be considered a good sample
Cosine Similarity
Too low, revise the signature selection
Summary: The total number of mutations is too low, this analysis should be revised and further bootstraps should be performed. Do not use this analysis.
Contributing Signatures:
| DBS3 | - | 47.31% |
| DBS10 | - | 34.55% |
| DBS2 | - | 8.53% |
| DBS1 | - | 8.09% |
No mutations found, do not consider as a good sample
Cosine Similarity
No matches, revise the signature selection
Summary: The total number of mutations is too low, this analysis should be revised and further bootstraps should be performed. Do not use this analysis.
No T-SNE plot can be displayed as no dimensionality_reduction .csv file was inputted. Please refer to Full Report Generation Documentation
Signature Databases
SBS96: COSMIC_v3.4_SBS_GRCh38
DBS78: COSMIC_v3.4_DBS_GRCh38
ID83: COSMIC_v3.4_ID_GRCh37
Fitting Method
Sigminer QP